Your Lab Partner 11.4

药物研发与高通量筛选利器

Drug Discovery & High-Throughput Screening Powerhouse

在药物研发领域，从先导化合物筛选到候选药物优化，每一个阶段都离不开大量的液体处理操作。梯度稀释、化合物筛选、ELISA 检测……这些重复性工作如果依赖手动完成，不仅效率低下，而且人为误差会直接影响筛选结果的可靠性。清风生化 MiniAssist 与 FlowHT，为药物研发实验室提供了从微量精准操作到大规模高通量筛选的全方位自动化解决方案。

In pharmaceutical research, from lead compound screening to candidate drug optimization, every stage relies on extensive liquid handling operations. Gradient dilution, compound screening, ELISA assays — if these repetitive tasks are performed manually, not only is efficiency compromised, but human error can directly compromise the reliability of screening results. GentleFlow's MiniAssist and FlowHT provide a comprehensive automation solution for drug discovery laboratories, from micro-volume precision operations to large-scale high-throughput screening.

MiniAssist：药物筛选的精准执行者

MiniAssist: The Precision Executor in Drug Screening

MiniAssist 在药物研发中扮演着不可替代的精准执行者角色：

·药物系列/梯度稀释自动化：通过智能软件预设稀释程序，MiniAssist 自动完成系列梯度稀释，显著提升药物筛选和活性检测的效率与准确性

·减少人为误差：自动化操作保证更好的一致性和可靠性，让每一次筛选结果都值得信赖

·ELISA 检测自动化：实现样品转移和试剂添加的全流程自动化，从包被到显色一步完成

·特别适合系列（梯度）稀释操作：8+1 通道模块设计使梯度稀释更加便捷和准确，是药物开发中不可或缺的高通量工具

MiniAssist plays an irreplaceable role as a precision executor in pharmaceutical research:

·Automated Serial / Gradient Dilution: Intelligent software pre-sets dilution protocols, and MiniAssist automatically completes serial gradient dilutions, significantly improving the efficiency and accuracy of drug screening and activity assays

·Reduced Human Error: Automated operations ensure better consistency and reliability, making every screening result trustworthy

·ELISA Assay Automation: Full-process automation from sample transfer to reagent addition, completing coating to color development in one step

·Ideal for Serial (Gradient) Dilution: The 8+1 channel module design makes gradient dilution more convenient and accurate — an indispensable high-throughput tool in drug development

FlowHT：大规模高通量筛选的加速引擎

FlowHT: The Acceleration Engine for Large-Scale HTS

FlowHT 以 96 通道同步移液能力，为大规模药物筛选提供强大的自动化引擎：

·系列稀释自动化：加载耗材和选择吸头后，自动执行系列稀释及其他复杂液体处理操作，无需人工干预

·偏置移液：通过选择性加载吸头实现非整板精确分液，适用于化合物库筛选和剂量响应实验

·连续分液：向细胞培养板或微孔板高效添加培养基和试剂，支持大规模细胞筛选

·反向移液：粘稠液体（如高浓度DMSO 溶液、细胞悬液）精准分配，确保加液体积准确

·移液前后混匀：防止细胞组分沉淀，高通量充分混合样品与反应试剂，确保筛选反应均一性

With 96-channel simultaneous pipetting capability, FlowHT provides a powerful automation engine for large-scale drug screening:

·Serial Dilution Automation: After loading consumables and selecting tips, automatically execute serial dilution and other complex liquid handling operations without manual intervention

·Offset Pipetting: Selective tip loading enables precise non-whole-plate dispensing, ideal for compound library screening and dose-response experiments

·Sequential Dispensing: Efficiently add media and reagents to cell culture plates or microplates, supporting large-scale cell-based screening

·Reverse Pipetting: Precise dispensing of viscous liquids (e.g., high-concentration DMSO solutions, cell suspensions) ensures accurate volumes

·Pre- and Post-Pipetting Mixing: Prevents cell component precipitation; high-throughput thorough mixing of samples and reagents ensures assay uniformity

数据说话：自动化带来的显著优势

By the Numbers: The Quantifiable Advantage of Automation

数据对比直观展现了自动化的巨大价值：

·传统手动8 道移液处理 96 孔板需 15–20 分钟 → FlowHT 96 通道仅需数秒，效率提升数十倍

·人工梯度稀释CV 值通常 > 5% → 自动化可控制在 < 3%，确保筛选结果的可靠性和可重复性

·人工操作漏加风险高→ 自动化整板同步移液，彻底消除漏加和重复加液问题

Data comparisons reveal the tremendous value of automation:

·Traditional manual 8-channel pipetting for a 96-well plate: 15–20 minutes → FlowHT 96-channel: mere seconds, improving efficiency by orders of magnitude

·Manual gradient dilution CV typically > 5% → Automation controls CV < 3%, ensuring reliable and reproducible screening results

·High risk of missed wells in manual operation → Automated whole-plate synchronized pipetting eliminates missed and duplicate additions entirely

▲ FlowHT — 高通量药物筛选的核心装备

让清风生化自动化加速您的药物研发管线！联系我们获取详细能力介绍。

Accelerate your drug discovery pipeline with GentleFlow automation. Get in touch for a detailed capability overview!